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Literature summary for 1.8.4.12 extracted from

  • Liang, X.; Fomenko, D.E.; Hua, D.; Kaya, A.; Gladyshev, V.N.
    Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing (2010), PLoS ONE, 5, e11497.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) and in HEK-293 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
nucleus
-
 Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5000
-
 MsrB1 occurs in two protein forms that migrate as 14000 and 5000 Da proteins, SDS-PAGE Mus musculus
14000
-
 MsrB1 occurs in two protein forms that migrate as 14000 and 5000 Da proteins, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Talon Co2+ affinity resin column chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver highest expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabsyl-L-methionine (R)-sulfoxide + dithiothreitol
-
 Mus musculus dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B1
-
 Mus musculus
MSRB1 previously known as SelR or SelX Mus musculus

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Mus musculus

General Information

General Information Comment Organism
physiological function oxidative stress can lead to oxidation of methionine residues, which are repaired by MsrB1 Mus musculus