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Literature summary for 1.8.4.12 extracted from

  • Weissbach, H.; Etienne, F.; Hoshi, T.; Heinemann, S.H.; Lowther, W.T.; Matthews, B.; St John, G.; Nathan, C.; Brot, N.
    Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function (2002), Arch. Biochem. Biophys., 397, 172-178.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
calmodulin-L-methionine (R)-sulfoxide + thioredoxin Escherichia coli
-
calmodulin-L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Escherichia coli substrates are peptides and proteins L-methionine + thioredoxin disulfide + H2O
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
in vivo MsrB activity is below detection limit Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calmodulin-L-methionine (R)-sulfoxide + thioredoxin
-
Escherichia coli calmodulin-L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + dithiothreitol
-
Escherichia coli L-methionine + dithiothreitol disulfide
-
?
L-methionine (R)-sulfoxide + thioredoxin
-
Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin substrates are peptides and proteins Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
?
additional information MsrB is specific for the R-form of the substrate Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
MsrB
-
Escherichia coli
peptide methionine sulfoxide reductase
-
Escherichia coli
YeaA
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
dithiothreitol utilized in vitro Escherichia coli
thioredoxin physiologic cofactor Escherichia coli