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Literature summary for 1.8.4.11 extracted from

  • Kim, H.Y.; Gladyshev, V.N.
    Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases (2006), BMC Mol. Biol., 7, 11.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genomic structure, alternative splicing variants, overview Homo sapiens
genomic structure, alternative splicing variants, overview Drosophila melanogaster
genomic structure, alternative splicing variants, overview, expression of GFP-tagged and/or His-tagged mitochondrial and cytosolic MsrAs in CV-1 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Drosophila melanogaster 5829
-
cytosol isozyme MsrA3 Homo sapiens 5829
-
cytosol splicing variant MsrA(S) Mus musculus 5829
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion mitochondrial splicing variant MsrA Mus musculus 5739
-
additional information subcellular localization is regulated by alternative splicing, overview Homo sapiens
-
-
additional information subcellular localization is regulated by alternative splicing, overview Drosophila melanogaster
-
-
additional information subcellular localization is regulated by alternative splicing, overview Mus musculus
-
-
nucleus
-
Homo sapiens 5634
-
nucleus splicing variant MsrA(S) Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P08761 gene Eip71CD or Eip28/29; alternative splicing variants, overview
-
Homo sapiens
-
alternative splicing variants, overview
-
Homo sapiens Q9UJ68 isozyme MsrA3; alternative splicing variants, overview
-
Mus musculus Q9D6Y7 alternative splicing variants, overview
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Drosophila melanogaster peptide-L-methionine + thioredoxin disulfide + H2O
-
?

Synonyms

Synonyms Comment Organism
ecdysone-induced protein 28/29 kDa
-
Drosophila melanogaster
methionine sulfoxide reductase A
-
Homo sapiens
methionine sulfoxide reductase A
-
Drosophila melanogaster
methionine sulfoxide reductase A
-
Mus musculus
MsrA
-
Homo sapiens
MsrA
-
Drosophila melanogaster
MsrA
-
Mus musculus
peptide methionine sulfoxide reductase
-
Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Drosophila melanogaster