Literature summary for 1.8.4.11 extracted from

Romero, H.M.; Berlett, B.S.; Jensen, P.J.; Pell, E.J.; Tien, M.
Investigations into the role of the plastidial peptide methionine sulfoxide reductase in response to oxidative stress in Arabidopsis (2004), Plant Physiol., 136, 3784-3794.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	effects of high light, ozone, and paraquat on enzyme activity and photosynthetic activity in wild-type and transgenic plants, overview	Arabidopsis thaliana

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of several transgenic plant lines with altered expression level of the plastidic isozyme PMSR4 of 40-600% compared to wild-type expression level, which results in no phenotype under optimal growing conditions, but at oxidative stress conditions differences in the photosynthesis rate, and the rate of oxidized methionine residues in the chloroplast occur, overexpressing plants are more resistant to oxidative stress, while antisense plants show increased sensitivity, expression analysis	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	effects of high light, ozone, and paraquat on enzyme activity and photosynthetic activity in wild-type and transgenic plants, overview	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
chloroplast	plastidial isozyme PMSR4, soluble fraction	Arabidopsis thaliana	9507	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein-L-methionine (S)-sulfoxide + thioredoxin	Arabidopsis thaliana	enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues	protein-L-methionine + thioredoxin disulfide + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	P54150	ecotype Columbia	-

Purification (Commentary)

Purification (Comment)	Organism
purification of chloroplasts from wild-type and transgenic plants	Arabidopsis thaliana

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	relative activity in chloroplasts of wild-type and transgenic plants	Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Fmoc-L-methionine (S)-sulfoxide + dithiothreitol	-	Arabidopsis thaliana	Fmoc-L-methionine + dithiothreitol disulfide + H2O	-	?
protein-L-methionine (S)-sulfoxide + thioredoxin	-	Arabidopsis thaliana	protein-L-methionine + thioredoxin disulfide + H2O	-	?
protein-L-methionine (S)-sulfoxide + thioredoxin	enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues	Arabidopsis thaliana	protein-L-methionine + thioredoxin disulfide + H2O	-	?

Synonyms

Synonyms	Comment	Organism
peptide methionine sulfoxide reductase	-	Arabidopsis thaliana
PMSR	-	Arabidopsis thaliana

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Arabidopsis thaliana

Cofactor

Cofactor	Comment	Organism	Structure
dithiothreitol	-	Arabidopsis thaliana
thioredoxin	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)