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Literature summary for 1.8.4.11 extracted from

  • Dhandayuthapani, S.; Blaylock, M.W.; Bebear, C.M.; Rasmussen, W.G.; Baseman, J.B.
    Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium (2001), J. Bacteriol., 183, 5645-5650.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.11

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of His10-tagged MsrA in Escherichia coli strain BL21(DE3) Mycoplasma genitalium

Protein Variants

Protein Variants Comment Organism
additional information msrA disruption mutants, constructed by insertion mutagenesis, show highly increased sensitivity to H2O2 and reduced capability to adhere to host cell surfaces for infection, overview Mycoplasma genitalium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycoplasma genitalium MsrA is a virulence determinant for the plant pathogen required for full virulence ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Mycoplasma genitalium stereospecific reduction of protein-bound methionine (S)-sulfoxide residues, the enzyme is involved in repair of oxidized proteins by reducing oxidized methionine residues, which is required for resistance to hydrogen peroxide and other reactive oxygen species, and for adherence to host cell surfaces peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mycoplasma genitalium
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-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His10-tagged MsrA from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Mycoplasma genitalium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MsrA is a virulence determinant for the plant pathogen required for full virulence Mycoplasma genitalium ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction of protein-bound methionine (S)-sulfoxide residues, the enzyme is involved in repair of oxidized proteins by reducing oxidized methionine residues, which is required for resistance to hydrogen peroxide and other reactive oxygen species, and for adherence to host cell surfaces Mycoplasma genitalium peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction of protein-bound methionine (S)-sulfoxide residues Mycoplasma genitalium peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MsrA
-
 Mycoplasma genitalium
peptide methionine sulfoxide reductase
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 Mycoplasma genitalium

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Mycoplasma genitalium