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Literature summary for 1.8.3.2 extracted from
- Purification and properties of the membranal thiol oxidase from porcine kidney (1986), Arch. Biochem. Biophys., 247, 120-130.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H2O2 | - |
Sus scrofa |  |
| L-(alphaS,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid | - |
Sus scrofa | |
| NEM | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.42 | - |
L-Cys | - |
Sus scrofa | |
| 0.51 | - |
dithiothreitol | - |
Sus scrofa | |
| 0.73 | - |
GSH | - |
Sus scrofa | |
| 1.6 | - |
cysteamine | - |
Sus scrofa | |
| 3.3 | - |
N-acetylcysteine | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Sus scrofa | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | contains 1 mol copper per subunit, in a binuclear complex | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
2 * 70000, also aggregates to larger multimers, SDS-PAGE | Sus scrofa |
| 120000 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | cortex | Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cysteamine + O2 | - |
Sus scrofa | ? + H2O | - |
? | |
| dithiothreitol + O2 | - |
Sus scrofa | ? + H2O | - |
? | |
| GSH + O2 + O2 | - |
Sus scrofa | GSSG + H2O | - |
? | |
| L-Cys + O2 | - |
Sus scrofa | ? + H2O | - |
? | |
| N-acetylcysteine + O2 | - |
Sus scrofa | ? + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 70000, also aggregates to larger multimers, SDS-PAGE | Sus scrofa |
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