Literature summary for 1.8.1.B1 extracted from

Li, T.; Ziniel, P.D.; He, P.Q.; Kommer, V.P.; Crowther, G.J.; He, M.; Liu, Q.; Van Voorhis, W.C.; Williams, D.L.; Wang, M.W.
High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis (2015), Infect. Dis. Poverty, 4, 40 .

Search for more literature for 1.8.1.B1

Inhibitors

Inhibitors	Comment	Organism	Structure
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one	at 0.010 microM, 100 % larval death at 48 hours	Schistosoma mansoni
5-bromo-N-ethyl-3,4-dinitrothiophen-2-amine	at 0.005 microM, 100 % larval death at 48 hours	Schistosoma mansoni
6-nitro-1H-1-benzothiophene-1,1-dione	at 0.010 microM, 100 % larval death at 48 hours	Schistosoma mansoni

Organism

Organism	UniProt	Comment	Textmining
Schistosoma mansoni	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0054	-	pH 7.5, 22°C	Schistosoma mansoni	6-nitro-1H-1-benzothiophene-1,1-dione
0.0063	-	pH 7.5, 22°C	Schistosoma mansoni	4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
3.15	-	pH 7.5, 22°C	Schistosoma mansoni	5-bromo-N-ethyl-3,4-dinitrothiophen-2-amine

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)