Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a drug target in schistosomiasis | Schistosoma mansoni |
Protein Variants | Comment | Organism |
---|---|---|
U597C | the mutant displays significantly decreased enzyme activities compared to the wild type enzyme | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | very potent inhibitor, nearly compete inhibition at 0.01 mM | Schistosoma mansoni | |
furoxan | i.e. oxadiazole-3-carbonitrile-2-oxide, potent inhibitor | Schistosoma mansoni |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Schistosoma mansoni | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
2 * 65000 | Schistosoma mansoni |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSSG + NADPH + H+ | Schistosoma mansoni | - |
GSH + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | Schistosoma mansoni | - |
thioredoxin + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | Q962Y6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Schistosoma mansoni | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
GSSG + NADPH + H+ | - |
Schistosoma mansoni | GSH + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Schistosoma mansoni | thioredoxin + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 65000 | Schistosoma mansoni |
Synonyms | Comment | Organism |
---|---|---|
TGR | also know as TXNRD3/TrxR3 | Schistosoma mansoni |
thioredoxin-glutathione reductase | - |
Schistosoma mansoni |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Schistosoma mansoni | |
NADPH | - |
Schistosoma mansoni |