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Literature summary for 1.8.1.B1 extracted from

  • Prast-Nielsen, S.; Huang, H.H.; Williams, D.L.
    Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases (2011), Biochim. Biophys. Acta, 1810, 1262-1271.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme is a drug target in schistosomiasis Schistosoma mansoni

Protein Variants

Protein Variants Comment Organism
U597C the mutant displays significantly decreased enzyme activities compared to the wild type enzyme Schistosoma mansoni

Inhibitors

Inhibitors Comment Organism Structure
auranofin very potent inhibitor, nearly compete inhibition at 0.01 mM Schistosoma mansoni
furoxan i.e. oxadiazole-3-carbonitrile-2-oxide, potent inhibitor Schistosoma mansoni

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Schistosoma mansoni 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
2 * 65000 Schistosoma mansoni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GSSG + NADPH + H+ Schistosoma mansoni
-
GSH + NADP+
-
?
thioredoxin disulfide + NADPH + H+ Schistosoma mansoni
-
thioredoxin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni Q962Y6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Schistosoma mansoni 2-nitro-5-thiobenzoate + NADP+
-
?
GSSG + NADPH + H+
-
Schistosoma mansoni GSH + NADP+
-
?
thioredoxin disulfide + NADPH + H+
-
Schistosoma mansoni thioredoxin + NADP+
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 65000 Schistosoma mansoni

Synonyms

Synonyms Comment Organism
TGR also know as TXNRD3/TrxR3 Schistosoma mansoni
thioredoxin-glutathione reductase
-
Schistosoma mansoni

Cofactor

Cofactor Comment Organism Structure
FAD
-
Schistosoma mansoni
NADPH
-
Schistosoma mansoni