Literature summary for 1.8.1.9 extracted from

Pirazzini, M.; Bordin, F.; Rossetto, O.; Shone, C.; Binz, T.; Montecucco, C.
The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals (2013), FEBS Lett., 587, 150-155 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
auranofin	protects cerebellar granular neurons from the action of different doses of tetanus neurotoxin, about 1 microM auranofinF confers a full protection against tetnus neurotoxin intoxication. Auranofin protects cerebellar granular neurons from the cleavage of VAMP-2 induced by botulinum neurotoxi B and the cleavage of syntaxin 1A induced by botulinum neurotoxin C	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	cerebellar granule neuron	Rattus norvegicus	-

General Information

General Information	Comment	Organism
physiological function	the thioredoxin system plays a major role in releasing the L chain of tetanus neurotoxin and botulinum neurotoxins after their translocation across the membrane of the endocytic vesicle	Rattus norvegicus

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Release 2023.1 (January 2023)