Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hg2+ | in the presence of NADPH, a ratio of 2 HgCl2 molecules to 1 TrxR dimer leads to a virtually inactive enzyme. On treatment with 0.005 mM selenite and NADPH, TrxR inactivated by HgCl2 displays almost full recovery of activity | Homo sapiens | |
Hg2+ | in the presence of NADPH, a ratio of 2 HgCl2 molecules to 1 TrxR dimer leads to a virtually inactive enzyme. On treatment with 0.005 mM selenite and NADPH, TrxR inactivated by HgCl2 displays almost full recovery of activity | Rattus norvegicus | |
methylmercury | in the case of methylmercury, a ratio of 16 molecules per dimer leads to a virtually inactive enzyme | Homo sapiens | |
methylmercury | in the case of methylmercury, a ratio of 16 molecules per dimer leads to a virtually inactive enzyme | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
2 * 58000, SDS-PAGE | Homo sapiens |
58000 | - |
2 * 58000, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin + NADPH + H+ | - |
Homo sapiens | ? + NADP+ | - |
? | |
insulin + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 58000, SDS-PAGE | Homo sapiens |
homodimer | 2 * 58000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Homo sapiens |
thioredoxin reductase | - |
Rattus norvegicus |
TrxR | - |
Homo sapiens |
TrxR | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the thioredoxin system, comprising thioredoxin, thioredoxin reductase, and NADPH, is critical for cellular stress response, protein repair, and protection against oxidative damage | Homo sapiens |
physiological function | the thioredoxin system, comprising thioredoxin, thioredoxin reductase, and NADPH, is critical for cellular stress response, protein repair, and protection against oxidative damage | Rattus norvegicus |