Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-dihydroxyanthroquinone | - |
Rattus norvegicus | |
1,8-dihydroxyanthroquinone | - |
Rattus norvegicus | |
aloe emodin | - |
Rattus norvegicus | |
aloin A | - |
Rattus norvegicus | |
anthrone | - |
Rattus norvegicus | |
chrysophanol | - |
Rattus norvegicus | |
frangulin A | - |
Rattus norvegicus | |
hypericin | - |
Rattus norvegicus | |
physcion | - |
Rattus norvegicus | |
pseudohypericin | strong inhibitor of isoform TrxR1 | Rattus norvegicus | |
Rhein | - |
Rattus norvegicus | |
sennoside A | - |
Rattus norvegicus | |
sennoside B | - |
Rattus norvegicus | |
skyrin glucoside | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform TrxR1 | Rattus norvegicus | 5829 | - |
mitochondrion | isoform TrxR2 | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin disulfide + NADPH + H+ | Rattus norvegicus | - |
thioredoxin + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | O89049 | isoform TrxR1 | - |
Rattus norvegicus | Q9Z0J5 | isoform TrxR2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Rattus norvegicus |
TrxR1 | isoform | Rattus norvegicus |
TrxR2 | isoform | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0046 | - |
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | pseudohypericin | |
0.0079 | - |
isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | pseudohypericin | |
0.049 | - |
isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | hypericin | |
0.084 | - |
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | Rhein | |
0.123 | - |
isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | Rhein | |
0.132 | - |
isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | physcion | |
0.18 | - |
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | aloe emodin | |
0.181 | - |
isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | chrysophanol | |
0.185 | - |
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | physcion | |
0.194 | - |
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | chrysophanol | |
0.198 | - |
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | hypericin | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | anthrone | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | 1,4-dihydroxyanthroquinone | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | 1,8-dihydroxyanthroquinone | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | aloin A | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | sennoside A | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | sennoside B | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | frangulin A | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | skyrin glucoside | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | anthrone | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | 1,4-dihydroxyanthroquinone | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | aloe emodin | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | aloin A | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | sennoside A | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | sennoside B | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | frangulin A | |
0.2 | - |
IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) | Rattus norvegicus | skyrin glucoside |