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Literature summary for 1.8.1.9 extracted from

  • Hondal, R.J.; Ruggles, E.L.
    Differing views of the role of selenium in thioredoxin reductase (2011), Amino Acids, 41, 73-89.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
mitochondrion
-
Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
selenium the enzyme possesses selenium in the form of selenocysteine in the active site Mus musculus
selenium the enzyme possesses selenium in the form of selenocysteine in the active site Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Mus musculus
-
thioredoxin + NADP+
-
?
thioredoxin disulfide + NADPH + H+ Rattus norvegicus
-
thioredoxin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+
-
Rattus norvegicus ?
-
?
juglone + NADPH + H+
-
Rattus norvegicus ?
-
?
lipoic acid + NADPH + H+
-
Mus musculus ?
-
?
selenite + NADPH + H2O
-
Mus musculus Se2- + NADP+ + ?
-
?
thioredoxin disulfide + NADPH + H+
-
Mus musculus thioredoxin + NADP+
-
?
thioredoxin disulfide + NADPH + H+
-
Rattus norvegicus thioredoxin + NADP+
-
?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Mus musculus
thioredoxin reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
FAD
-
Rattus norvegicus
NADPH
-
Mus musculus
NADPH
-
Rattus norvegicus