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Literature summary for 1.8.1.9 extracted from

  • Zhang, Z.; Bao, R.; Zhang, Y.; Yu, J.; Zhou, C.Z.; Chen, Y.
    Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin (2009), Biochim. Biophys. Acta, 1794, 124-128.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 0.1 M MES buffer, pH 6.5, 10% (w/v) PEG 20000, at 18°C Saccharomyces cerevisiae
hanging drop vapor diffusion method, using 0.1 M MES buffer, pH 6.5, 10% PEG 20000, at 18°C Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Saccharomyces cerevisiae 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Saccharomyces cerevisiae
-
thioredoxin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P29509
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA affinity column chromatography, gel filtration Saccharomyces cerevisiae
Ni-NTA column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Saccharomyces cerevisiae 2-nitro-5-thiobenzoate + NADP+
-
?
thioredoxin disulfide + NADPH + H+
-
Saccharomyces cerevisiae thioredoxin + NADP+
-
?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Saccharomyces cerevisiae
Trr1
-
Saccharomyces cerevisiae
Trr1 isoform Saccharomyces cerevisiae
TRR2 isoform Saccharomyces cerevisiae
Trx3 isoform Saccharomyces cerevisiae
TrxR
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
FAD
-
Saccharomyces cerevisiae
FAD one FAD molecule is incorporated in each subunit Saccharomyces cerevisiae
NADPH
-
Saccharomyces cerevisiae