Literature summary for 1.8.1.9 extracted from

Soerensen, J.; Jakupoglu, C.; Beck, H.; Foerster, H.; Schmidt, J.; Schmahl, W.; Schweizer, U.; Conrad, M.; Brielmeier, M.
The role of thioredoxin reductases in brain development (2008), PLoS ONE, 3, e1813.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mus musculus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JLT4	-	-
Mus musculus	Q9JMH6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
nervous system	mice lacking Txnrd1 in the nervous system are significantly smaller and display ataxia and tremor. A strikingly patterned cerebellar hypoplasia is observed. Proliferation of the external granular layer is strongly reduced and fissure formation and laminar organisation of the cerebellar cortex is impaired in the rostral portion of the cerebellum. Purkinje cells are ectopically located and their dendrites stunted. The Bergmann glial network is disorganized and shows a pronounced reduction in fiber strength. Neuron-specific inactivation of Txnrd1 does not result in cerebellar hypoplasia, suggesting a vital role for Txnrd1 in Bergmann glia or neuronal precursor cells	Mus musculus	-
nervous system	nervous system-specific Txnrd2 null mice develop normally	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Txnrd1	-	Mus musculus
Txnrd2	-	Mus musculus

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Release 2023.1 (January 2023)