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Literature summary for 1.8.1.9 extracted from

  • Peng, Z.F.; Lan, L.X.; Zhao, F.; Li, J.; Tan, Q.; Yin, H.W.; Zeng, H.H.
    A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells (2008), J. Zhejiang Univ. Sci. B, 9, 16-21.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.9

Application

Application Comment Organism
medicine tumor-bearing mice treated with 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane shows an increase of life span with a comparable effect to cyclophosphamide. Potential usage of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane as a therapeutic agent against non-solid tumors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane apoptosis induced by the inhibitor is through Bcl-2/Bax and caspase-3 pathways Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Homo sapiens
TrxR
-
 Homo sapiens