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Literature summary for 1.8.1.9 extracted from

  • Liu, Z.; Du, Z.Y.; Huang, Z.S.; Lee, K.S.; Gu, L.Q.
    Inhibition of thioredoxin reductase by curcumin analogs (2008), Biosci. Biotechnol. Biochem., 72, 2214-2218.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1E,4E)-1,5-bis(3,4-dihydroxyphenyl)penta-1,4-dien-3-one
-
Sus scrofa
(1E,4E)-1,5-bis(3,5-di-tert-butyl-4-hydroxyphenyl)penta-1,4-dien-3-one
-
Sus scrofa
(1E,4E)-1,5-bis(3-bromo-4-hydroxy-5-methoxyphenyl)penta-1,4-dien-3-one
-
Sus scrofa
(1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one
-
Sus scrofa
(1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one
-
Sus scrofa
(2E,5E)-2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone
-
Sus scrofa
(2E,5E)-2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone
-
Sus scrofa
(2E,5E)-2,5-bis(4-hydroxybenzylidene)cyclopentanone
-
Sus scrofa
(2E,5E)-2,5-bis[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]cyclopentanone
-
Sus scrofa
(2E,5E)-2,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclopentanone
-
Sus scrofa
(2E,6E)-2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone
-
Sus scrofa
(2E,6E)-2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone
-
Sus scrofa
(2E,6E)-2,6-bis(4-hydroxybenzylidene)cyclohexanone
-
Sus scrofa
(2E,6E)-2,6-bis[(3,4-dimethoxyphenyl)methylidene]cyclohexanone
-
Sus scrofa
(2E,6E)-2,6-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclohexanone
-
Sus scrofa
(3E,5E)-3,5-bis(3,4-dihydroxybenzylidene)piperidin-4-one
-
Sus scrofa
(3E,5E)-3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)piperidin-4-one
-
Sus scrofa
(3E,5E)-3,5-bis(4-hydroxybenzylidene)-4-oxopiperidinium
-
Sus scrofa
(3E,5E)-3,5-bis[(3,4-dimethoxyphenyl)methylidene]piperidin-4-one
-
Sus scrofa
(3E,5E)-3,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]piperidin-4-one
-
Sus scrofa
(3E,5E)-3-[(2,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]piperidin-4-one
-
Sus scrofa
curcumin
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Sus scrofa 2-nitro-5-thiobenzoate + NADP+
-
?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Sus scrofa
TrxR
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00052
-
pH 7.4, 25°C Sus scrofa (2E,5E)-2,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclopentanone
0.00086
-
pH 7.4, 25°C Sus scrofa (3E,5E)-3,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]piperidin-4-one
0.0017
-
pH 7.4, 25°C Sus scrofa (1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one
0.0018
-
pH 7.4, 25°C Sus scrofa (1E,4E)-1,5-bis(3,4-dihydroxyphenyl)penta-1,4-dien-3-one
0.003
-
pH 7.4, 25°C Sus scrofa (1E,4E)-1,5-bis(3-bromo-4-hydroxy-5-methoxyphenyl)penta-1,4-dien-3-one
0.0033
-
pH 7.4, 25°C Sus scrofa (2E,5E)-2,5-bis(4-hydroxybenzylidene)cyclopentanone
0.0042
-
pH 7.4, 25°C Sus scrofa (2E,5E)-2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone
0.0046
-
pH 7.4, 25°C Sus scrofa (3E,5E)-3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)piperidin-4-one
0.0048
-
pH 7.4, 25°C Sus scrofa (2E,6E)-2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone
0.0063
-
pH 7.4, 25°C Sus scrofa (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one
0.0064
-
pH 7.4, 25°C Sus scrofa (2E,6E)-2,6-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclohexanone
0.0081
-
pH 7.4, 25°C Sus scrofa (2E,5E)-2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone
0.0089
-
pH 7.4, 25°C Sus scrofa (2E,6E)-2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone
0.0137
-
pH 7.4, 25°C Sus scrofa (1E,4E)-1,5-bis(3,5-di-tert-butyl-4-hydroxyphenyl)penta-1,4-dien-3-one
0.0184
-
pH 7.4, 25°C Sus scrofa (3E,5E)-3-[(2,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]piperidin-4-one
0.0241
-
pH 7.4, 25°C Sus scrofa (2E,6E)-2,6-bis(4-hydroxybenzylidene)cyclohexanone
0.0306
-
pH 7.4, 25°C Sus scrofa (3E,5E)-3,5-bis[(3,4-dimethoxyphenyl)methylidene]piperidin-4-one
0.0382
-
pH 7.4, 25°C Sus scrofa curcumin
0.0407
-
pH 7.4, 25°C Sus scrofa (2E,5E)-2,5-bis[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]cyclopentanone
0.0453
-
pH 7.4, 25°C Sus scrofa (2E,6E)-2,6-bis[(3,4-dimethoxyphenyl)methylidene]cyclohexanone
0.0462
-
pH 7.4, 25°C Sus scrofa (3E,5E)-3,5-bis(3,4-dihydroxybenzylidene)piperidin-4-one
0.071
-
pH 7.4, 25°C Sus scrofa (3E,5E)-3,5-bis(4-hydroxybenzylidene)-4-oxopiperidinium