Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1E,4E)-1,5-bis(3,4-dihydroxyphenyl)penta-1,4-dien-3-one | - |
Sus scrofa | |
(1E,4E)-1,5-bis(3,5-di-tert-butyl-4-hydroxyphenyl)penta-1,4-dien-3-one | - |
Sus scrofa | |
(1E,4E)-1,5-bis(3-bromo-4-hydroxy-5-methoxyphenyl)penta-1,4-dien-3-one | - |
Sus scrofa | |
(1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one | - |
Sus scrofa | |
(1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one | - |
Sus scrofa | |
(2E,5E)-2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone | - |
Sus scrofa | |
(2E,5E)-2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone | - |
Sus scrofa | |
(2E,5E)-2,5-bis(4-hydroxybenzylidene)cyclopentanone | - |
Sus scrofa | |
(2E,5E)-2,5-bis[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]cyclopentanone | - |
Sus scrofa | |
(2E,5E)-2,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclopentanone | - |
Sus scrofa | |
(2E,6E)-2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone | - |
Sus scrofa | |
(2E,6E)-2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone | - |
Sus scrofa | |
(2E,6E)-2,6-bis(4-hydroxybenzylidene)cyclohexanone | - |
Sus scrofa | |
(2E,6E)-2,6-bis[(3,4-dimethoxyphenyl)methylidene]cyclohexanone | - |
Sus scrofa | |
(2E,6E)-2,6-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclohexanone | - |
Sus scrofa | |
(3E,5E)-3,5-bis(3,4-dihydroxybenzylidene)piperidin-4-one | - |
Sus scrofa | |
(3E,5E)-3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)piperidin-4-one | - |
Sus scrofa | |
(3E,5E)-3,5-bis(4-hydroxybenzylidene)-4-oxopiperidinium | - |
Sus scrofa | |
(3E,5E)-3,5-bis[(3,4-dimethoxyphenyl)methylidene]piperidin-4-one | - |
Sus scrofa | |
(3E,5E)-3,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]piperidin-4-one | - |
Sus scrofa | |
(3E,5E)-3-[(2,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]piperidin-4-one | - |
Sus scrofa | |
curcumin | - |
Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Sus scrofa | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Sus scrofa |
TrxR | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00052 | - |
pH 7.4, 25°C | Sus scrofa | (2E,5E)-2,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclopentanone | |
0.00086 | - |
pH 7.4, 25°C | Sus scrofa | (3E,5E)-3,5-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]piperidin-4-one | |
0.0017 | - |
pH 7.4, 25°C | Sus scrofa | (1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one | |
0.0018 | - |
pH 7.4, 25°C | Sus scrofa | (1E,4E)-1,5-bis(3,4-dihydroxyphenyl)penta-1,4-dien-3-one | |
0.003 | - |
pH 7.4, 25°C | Sus scrofa | (1E,4E)-1,5-bis(3-bromo-4-hydroxy-5-methoxyphenyl)penta-1,4-dien-3-one | |
0.0033 | - |
pH 7.4, 25°C | Sus scrofa | (2E,5E)-2,5-bis(4-hydroxybenzylidene)cyclopentanone | |
0.0042 | - |
pH 7.4, 25°C | Sus scrofa | (2E,5E)-2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone | |
0.0046 | - |
pH 7.4, 25°C | Sus scrofa | (3E,5E)-3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)piperidin-4-one | |
0.0048 | - |
pH 7.4, 25°C | Sus scrofa | (2E,6E)-2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone | |
0.0063 | - |
pH 7.4, 25°C | Sus scrofa | (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one | |
0.0064 | - |
pH 7.4, 25°C | Sus scrofa | (2E,6E)-2,6-bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclohexanone | |
0.0081 | - |
pH 7.4, 25°C | Sus scrofa | (2E,5E)-2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone | |
0.0089 | - |
pH 7.4, 25°C | Sus scrofa | (2E,6E)-2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone | |
0.0137 | - |
pH 7.4, 25°C | Sus scrofa | (1E,4E)-1,5-bis(3,5-di-tert-butyl-4-hydroxyphenyl)penta-1,4-dien-3-one | |
0.0184 | - |
pH 7.4, 25°C | Sus scrofa | (3E,5E)-3-[(2,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]piperidin-4-one | |
0.0241 | - |
pH 7.4, 25°C | Sus scrofa | (2E,6E)-2,6-bis(4-hydroxybenzylidene)cyclohexanone | |
0.0306 | - |
pH 7.4, 25°C | Sus scrofa | (3E,5E)-3,5-bis[(3,4-dimethoxyphenyl)methylidene]piperidin-4-one | |
0.0382 | - |
pH 7.4, 25°C | Sus scrofa | curcumin | |
0.0407 | - |
pH 7.4, 25°C | Sus scrofa | (2E,5E)-2,5-bis[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]cyclopentanone | |
0.0453 | - |
pH 7.4, 25°C | Sus scrofa | (2E,6E)-2,6-bis[(3,4-dimethoxyphenyl)methylidene]cyclohexanone | |
0.0462 | - |
pH 7.4, 25°C | Sus scrofa | (3E,5E)-3,5-bis(3,4-dihydroxybenzylidene)piperidin-4-one | |
0.071 | - |
pH 7.4, 25°C | Sus scrofa | (3E,5E)-3,5-bis(4-hydroxybenzylidene)-4-oxopiperidinium |