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Literature summary for 1.8.1.9 extracted from
- Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo (2006), J. Am. Chem. Soc., 128, 1879-1885.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxy-2-nonenal | 0.005-0.025 mM, IC50: 0.0038 mM, irreversible inhibition; 0.05 mM, remarkable lost inhibition | Rattus norvegicus |  |
| curcumin | IC50: 0.0036 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | - |
Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP | - |
? | |
| thioredoxin + NADP+ | - |
Rattus norvegicus | thioredoxin disulfide + NADPH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase | - |
Rattus norvegicus |
| TrxR | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0036 | - |
IC50: 0.0036 mM | Rattus norvegicus | curcumin | |
| 0.0038 | - |
0.005-0.025 mM, IC50: 0.0038 mM, irreversible inhibition | Rattus norvegicus | 4-hydroxy-2-nonenal | |
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