Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cysteine | part of the active site | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | target for immunostimulating effect of 1-chloro-2,4-dinitrobenzene as agent in AIDS treatment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-chloro-2,4-dinitrobenzene | i.e. DNCB; irreversible, with NADPH, alkylation of the active site cysteine disulfide, strong increase in oxidation activity of the enzyme against NADPH | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ | inhibition mechanism | Homo sapiens | |
thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ | electron transfer in the enzyme complex of apoenzyme, FAD and thioredoxin with NADPH | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin + NADP+ | coupled assay with DTNB | Homo sapiens | thioredoxin disulfide + NADPH | - |
r | |
thioredoxin + NADP+ | - |
Homo sapiens | thioredoxin disulfide + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |