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Literature summary for 1.8.1.7 extracted from

  • Couto, N.; Malys, N.; Gaskell, S.J.; Barber, J.
    Partition and turnover of glutathione reductase from Saccharomyces cerevisiae a proteomic approach (2013), J. Proteome Res., 12, 2885-2894 .
    View publication on PubMed
Search for more literature for 1.8.1.7

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Saccharomyces cerevisiae BY4742
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Expression

Organism Comment Expression
Saccharomyces cerevisiae gene GLR1 uses alternative start codons to generate two forms of enzyme. Translation from the first AUG codon generates the mitochondrial form incorporating a presequence necessary for import, while translation from the second AUG codon yields the cytosolic counterpart. The N-terminus of cytosolic GLR1 normally is N-acetylserine. In a GLR1-overproducing strain, unprocessed mitochondrial GLR1 with N-terminal acetylmethionine also accumulates in the cytosol. The processed mitochondrial GLR1 has three alternative N-termini, none of them acetylated. Mitochondrial GLR1 is turned over faster than the cytosolic form by a factor of about 2. The second AUG appears to be responsible for most of the cellular GLR1 additional information

General Information

General Information Comment Organism
metabolism gene GLR1 uses alternative start codons to generate two forms of enzyme. Translation from the first AUG codon generates the mitochondrial form incorporating a presequence necessary for import, while translation from the second AUG codon yields the cytosolic counterpart. The N-terminus of cytosolic GLR1 normally is N-acetylserine. In a GLR1-overproducing strain, unprocessed mitochondrial GLR1 with N-terminal acetylmethionine also accumulates in the cytosol. The processed mitochondrial GLR1 has three alternative N-termini, none of them acetylated. Mitochondrial GLR1 is turned over faster than the cytosolic form by a factor of about 2. The second AUG appears to be responsible for most of the cellular GLR1 Saccharomyces cerevisiae