Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.7 extracted from

  • Adem, S.; Ciftci, M.
    Purification and Characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase from rat heart and inhibition effects of furosemide, digoxin, and dopamine on the enzymes aActivities (2016), J. Biochem. Mol. Toxicol., 30, 295-301 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
digoxin noncompetitive Rattus norvegicus
dopamine competitive Rattus norvegicus
Furosemide noncompetitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
NADPH 25°C, pH not specified in the publication Rattus norvegicus
0.037
-
glutathione disulfide 25°C, pH not specified in the publication Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
121000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
101.8
-
25°C, pH not specified in the publication Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Rattus norvegicus 2 glutathione + NADP+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 61000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
65
-
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.5
-
stable for 3 days Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.09
-
25°C, pH not specified in the publication Rattus norvegicus Furosemide
0.22
-
25°C, pH not specified in the publication Rattus norvegicus digoxin
23.9
-
25°C, pH not specified in the publication Rattus norvegicus dopamine