Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADP+ | competitive | Haemonchus contortus | |
Zn2+ | 2 mM, complete inhibition | Haemonchus contortus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.089 | - |
glutathione disulfide | pH 7.8, 37°C | Haemonchus contortus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | Ba2+, Mn2+, and Mg2+ in a range of 0.01-5 mM have no effect on TrxR3 activity | Haemonchus contortus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
134000 | - |
gel filtration | Haemonchus contortus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemonchus contortus | CDJ91018 | thioredoxin reductase, EC 1.8.1.9, with additional glutathione reductase activity | - |
Purification (Comment) | Organism |
---|---|
- |
Haemonchus contortus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.118 | - |
pH 7.8, 37°C | Haemonchus contortus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Haemonchus contortus | 2 glutathione + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 67000, SDS-PAGE | Haemonchus contortus |
Synonyms | Comment | Organism |
---|---|---|
HCOI_01258400 | - |
Haemonchus contortus |
TrxR3 | - |
Haemonchus contortus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
stable for 20 min | Haemonchus contortus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.95 | - |
glutathione disulfide | pH 7.8, 37°C | Haemonchus contortus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Haemonchus contortus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.92 | - |
pH 7.8, 37°C | Haemonchus contortus | Zn2+ |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.95 | - |
glutathione disulfide | pH 7.8, 37°C | Haemonchus contortus |