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Literature summary for 1.8.1.7 extracted from

  • Tandogan, B.; Ulusu, N.N.
    Comparative in vitro effects of some metal ions on bovine kidney cortex glutathione reductase (2010), Prep. Biochem. Biotechnol., 40, 405-411.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ noncompetitive inhibition with respect to both glutathione disulfide and NADPH Bos taurus
Ni2+ noncompetitive inhibition with respect to glutathione disulfide and uncompetitive with respect to NADPH Bos taurus
Zn2+ noncompetitive inhibition with respect to both glutathione disulfide and NADPH Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Bos taurus
-
glutathione + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
renal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Bos taurus glutathione + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.027
-
pH and temperature not specified in the publication Bos taurus Cd2+
0.8
-
pH and temperature not specified in the publication Bos taurus Ni2+
1
-
pH and temperature not specified in the publication Bos taurus Zn2+