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Literature summary for 1.8.1.7 extracted from

  • Liu, X.; Sturla, S.J.
    Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues (2009), Mol. Biosyst., 5, 1013-1024.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
acylfulvene reversible inhibition, less than 10% residual activity at 1.25 mM, inhibition by 1.0 or 1.25 mM acylfulvene is reduced by 30% in the presence of NDPH Saccharomyces cerevisiae
carmustine i.e. 1,3-bis(2-chloroethyl)-1-nitroso-urea, irreversible inhibitor, complete inhibition at 0.625 mM Saccharomyces cerevisiae
hydroxymethylacylfulvene irreversible inhibition, less than 10% residual activity at 1.25 mM, inhibition by 0.625 or 1.25 mM hydroxymethylacylfulvene is reduced by 45% in the presence of NDPH Saccharomyces cerevisiae
illudin S
-
 Saccharomyces cerevisiae
additional information up to 2 mM, illudin S does not inhibit glutathione reductase activity Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Saccharomyces cerevisiae glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
EC 1.6.4.2 formerly Saccharomyces cerevisiae
glutathione reductase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Saccharomyces cerevisiae
NADPH
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.18
-
 hydroxymethylacylfulvene at 25°C, pH not specified in the publication Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.071
-
 at 25°C, pH not specified in the publication Saccharomyces cerevisiae carmustine
0.216
-
 at 25°C, pH not specified in the publication Saccharomyces cerevisiae hydroxymethylacylfulvene
0.871
-
 at 25°C, pH not specified in the publication Saccharomyces cerevisiae acylfulvene