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Literature summary for 1.8.1.7 extracted from

  • Iribarne, F.; Paulino, M.; Aguilera, S.; Tapia, O.
    Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and Molecular Dynamics studies (2009), J. Mol. Graph. Model., 28, 371-381.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
Homo sapiens
N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
-
Homo sapiens
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
-
Homo sapiens
N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-aminium
-
Homo sapiens
N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-aminium
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Homo sapiens
-
glutathione + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00390
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens