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Literature summary for 1.8.1.7 extracted from

  • Senturk, M.; Irfan Kufrevioglu, O.; Ciftci, M.
    Effects of some analgesic anaesthetic drugs on human erythrocyte glutathione reductase: an in vitro study (2009), J. Enzyme Inhib. Med. Chem., 24, 420-424.
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
diclofenac sodium competitive inhibition Homo sapiens
etomidate competitive inhibition Homo sapiens
Ketoprofen competitive inhibition Homo sapiens
lornoxicam competitive inhibition Homo sapiens
morphine competitive inhibition Homo sapiens
propofol noncompetitive inhibition Homo sapiens
tenoxicam competitive inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B column chromatography and Sephadex G-200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0097
-
 hemolysate, at 25°C, pH 8.0 Homo sapiens
20.75
-
 after 2139fold purification, at 25°C, pH 8.0 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 r

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0165
-
 morphine in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
0.0725
-
 etomidate in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
0.13
-
 tenoxicam in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
0.418
-
 propofol in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
0.42
-
 lornoxicam in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
22.14
-
 Ketoprofen in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
23.97
-
 diclofenac sodium in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0128
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens morphine
0.0523
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens etomidate
0.082
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens tenoxicam
0.242
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens propofol
0.3
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens lornoxicam
6.278
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens Ketoprofen
7.265
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens diclofenac sodium