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Literature summary for 1.8.1.7 extracted from
- Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo (2005), J. Enzyme Inhib. Med. Chem., 20, 69-74.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ampicillin | leads to slight activation in vivo | Rattus norvegicus |  |
| gentamycin sulfate | leads to slight activation in vivo | Rattus norvegicus | |
| penicillin G | leads to slight activation in vivo | Rattus norvegicus | |
| streptomycin sulfate | leads to slight activation in vivo | Rattus norvegicus | |
| teicoplanin | leads to slight activation in vivo | Rattus norvegicus | |
| Thiamphenicol | leads to slight activation in vivo | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cefodizime | competitive inhibition, in vitro | Homo sapiens | |
| cefodizime | competitive, 21% inhibition in vivo, effect decreases with time | Rattus norvegicus | |
| cefotaxime | noncompetitive inhibition, in vitro | Homo sapiens | |
| cefotaxime | noncompetitive, 46% inhibition in vivo, effect decreases with time | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione disulfide + NADPH | Homo sapiens | - |
glutathione + NADP+ | - |
? | |
| glutathione disulfide + NADPH | Rattus norvegicus | - |
glutathione + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 5342fold to homogeneity from erythrocytes by hemolysis, ammonium sulfate fractionation, affinity chromatography, and gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 50.75 | - |
purified erythrocyte enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione disulfide + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
| glutathione disulfide + NADPH | - |
Rattus norvegicus | glutathione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione reductase | - |
Homo sapiens |
| glutathione reductase | - |
Rattus norvegicus |
| GR | - |
Homo sapiens |
| GR | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.745 | - |
cefodizime | pH 8.0, 25°C | Homo sapiens | |
| 6.51 | - |
cefotaxime | pH 8.0, 25°C | Homo sapiens | |
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