Any feedback?
Literature summary for 1.8.1.4 extracted from
- Changes in dihydrolipoamide dehydrogenase expression and activity during postnatal development and aging in the rat brain (2008), Mech. Ageing Dev., 129, 282-290.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activity of DLDH dehydrogenase increases in rats between 10 and 20 days of age. Dehydrogenase activity of DLDH shows a further, progressive increase in rats from 20 days to adulthood, in the absence of any further change in DLDH expression or diaphorase activity | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | brain DLDH expression and activity undergo independent postnatal maturational increases. Senescence does not confer any detectable change in the activity of DLDH or its susceptibility to inactivation by mitochondrial oxidative stress | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no age-related decline in DLDH activity or expression is evident in rats over the period from 5 to 30 months of age. Lower DLDH dehydrogenase activity observed in pups may be due to NADH inhibition | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
female and male Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult | - |
Rattus norvegicus | - |
| brain | 30% increase in DLDH expression in rats between 10 and 20 days of age, whereas there is no further increase during the period from 20 to 60 days. Diaphorase activity shows a 46% increase in rats between 10 and 20 days of age, but there is also no further increase between 20 and 60 days. DLDH dehydrogenase activity increases progressively over the period from 10 to 60 days of age (63% between 10 and 20 days, 30% between 20 and 30 days, and 25% between 30 and 60 days of age) | Rattus norvegicus | - |
| heart | significant increase in DLDH dehydrogenase activity in rats only for the period between 30 and 60 days of age | Rattus norvegicus | - |
| kidney | significant increase in DLDH dehydrogenase activity in rats only for the period between 30 and 60 days of age | Rattus norvegicus | - |
| liver | increase in DLDH dehydrogenase activity in rats between 10 and 20 days of age, with no further increase evident thereafter | Rattus norvegicus | - |
| pup | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | - |
Rattus norvegicus | lipoamide + NADH | - |
r |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydrolipoamide dehydrogenase | - |
Rattus norvegicus |
| DLDH | - |
Rattus norvegicus |
| DLDH diaphorase | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
