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Literature summary for 1.8.1.4 extracted from

  • Tahara, E.B.; Barros, M.H.; Oliveira, G.A.; Netto, L.E.; Kowaltowski, A.J.
    Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging (2007), FASEB J., 21, 274-283.
    View publication on PubMed
Search for more literature for 1.8.1.4

Application

Application Comment Organism
medicine dihydrolipoyl dehydrogenase is an important source of reactive oxygen species leading to life span limitation Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information deletion of the LPD1 gene prevents oxidative stress in npt1DELTA and bna6DELTA mutants Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibited by caloric restriction Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrolipoamide + NAD+
-
 Saccharomyces cerevisiae lipoamide + NADH + H+
-
 ?
O2 + NADH + H+
-
 Saccharomyces cerevisiae H2O2 + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
dihydrolipoamide dehydrogenase
-
 Saccharomyces cerevisiae
LPD1
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae
NADH
-
 Saccharomyces cerevisiae