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Literature summary for 1.8.1.15 extracted from
- Biosynthesis and functions of mycothiol, the unique protective thiol of actinobacteria (2008), Microbiol. Mol. Biol. Rev., 72, 471-494.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AcCys-GlcN + NADPH | - |
Mycobacterium tuberculosis | ? | - |
? |  |
| AcCys-GlcN-1-O-CH2Ph + NADPH | - |
Mycobacterium tuberculosis | ? | - |
? | |
| AcCys-GlcN-1-O-CH3 + NADPH | - |
Mycobacterium tuberculosis | ? | - |
? | |
| des-myo-inositol mycothione + NADH | - |
Mycobacterium tuberculosis | ? | - |
? | |
| mycothione + NADPH | - |
Mycobacterium tuberculosis | mycothiol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MSH disulfide reductase | - |
Mycobacterium tuberculosis |
| MTR | - |
Mycobacterium tuberculosis |
| mycothione reductase | - |
Mycobacterium tuberculosis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 20 | - |
NADH | 25°C | Mycobacterium tuberculosis | |
| 129 | - |
NADPH | 25°C | Mycobacterium tuberculosis | |
| 190 | - |
NADP+ | 25°C | Mycobacterium tuberculosis | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mycobacterium tuberculosis | |
| NADPH | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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