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Literature summary for 1.8.1.12 extracted from

  • da Silva, A.D.; Dos Santos, J.A.; Machado, P.A.; Alves, L.A.; Laque, L.C.; de Souza, V.C.; Coimbra, E.S.; Capriles, P.V.S.Z.
    Insights about resveratrol analogs against trypanothione reductase of Leishmania braziliensis Molecular modeling, computational docking and in vitro antileishmanial studies (2019), J. Biomol. Struct. Dyn., 37, 2960-2969 .
    View publication on PubMed
Search for more literature for 1.8.1.12

Inhibitors

Inhibitors Comment Organism Structure
additional information insights about resveratrol analogs against trypanothione reductase. Molecular modeling, computational docking and in vitro antileishmanial studies Leishmania braziliensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trypanothione disulfide + NADPH + H+ Leishmania braziliensis
-
 trypanothione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania braziliensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH + H+
-
 Leishmania braziliensis trypanothione + NADP+
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Leishmania braziliensis

Synonyms

Synonyms Comment Organism
LbTryR
-
 Leishmania braziliensis
trypanothione reductase
-
 Leishmania braziliensis

General Information

General Information Comment Organism
drug target a promising target for the development of new chemotherapeutics to treat leishmaniasis and Chagas disease. The enzyme is a specific protein in Trypanosomatidae family and is used by the parasite as a strategy for drug resistance. The enzyme is absent in human Leishmania braziliensis
physiological function the enzyme is an essential component of the antioxidant defenses in trypanosomatid parasites Leishmania braziliensis