Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride | non-competitive inhibition, 76% inhibition at 0.001 mM | Leishmania amazonensis | |
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride | non-competitive inhibition, 69.5% inhibition at 0.001 mM | Leishmania braziliensis | |
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride | non-competitive inhibition, 70% inhibition at 0.001 mM | Leishmania infantum | |
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride | non-competitive inhibition, 83% inhibition at 0.001 mM | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | Trypanosoma cruzi | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Leishmania amazonensis | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Leishmania infantum | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Leishmania braziliensis | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Trypanosoma cruzi Y | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Leishmania amazonensis MHOM/BR/LTB0016 | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Leishmania infantum MHOM/MA67ITMAP263 | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | Leishmania braziliensis MCAN/BR/98/R619 | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania amazonensis | - |
- |
- |
Leishmania amazonensis MHOM/BR/LTB0016 | - |
- |
- |
Leishmania braziliensis | - |
- |
- |
Leishmania braziliensis MCAN/BR/98/R619 | - |
- |
- |
Leishmania infantum | - |
- |
- |
Leishmania infantum MHOM/MA67ITMAP263 | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Trypanosoma cruzi Y | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epimastigote | - |
Trypanosoma cruzi | - |
epimastigote | - |
Leishmania amazonensis | - |
epimastigote | - |
Leishmania infantum | - |
epimastigote | - |
Leishmania braziliensis | - |
promastigote | - |
Trypanosoma cruzi | - |
promastigote | - |
Leishmania amazonensis | - |
promastigote | - |
Leishmania infantum | - |
promastigote | - |
Leishmania braziliensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Leishmania amazonensis | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Leishmania infantum | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Leishmania braziliensis | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi Y | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Leishmania amazonensis MHOM/BR/LTB0016 | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Leishmania infantum MHOM/MA67ITMAP263 | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Leishmania braziliensis MCAN/BR/98/R619 | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma cruzi |
trypanothione reductase | - |
Leishmania amazonensis |
trypanothione reductase | - |
Leishmania infantum |
trypanothione reductase | - |
Leishmania braziliensis |
TryR | - |
Trypanosoma cruzi |
TryR | - |
Leishmania amazonensis |
TryR | - |
Leishmania infantum |
TryR | - |
Leishmania braziliensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma cruzi | |
FAD | - |
Leishmania amazonensis | |
FAD | - |
Leishmania infantum | |
FAD | - |
Leishmania braziliensis | |
NADPH | - |
Trypanosoma cruzi | |
NADPH | - |
Leishmania amazonensis | |
NADPH | - |
Leishmania infantum | |
NADPH | - |
Leishmania braziliensis |