Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,6-dimethyl-3-(4-methylphenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | linear uncompetitive mode of inhibition | Trypanosoma brucei | |
1-ethyl-6-methyl-3-(pyridin-3-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
1-ethyl-6-methyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | linear uncompetitive mode of inhibition | Trypanosoma brucei | |
1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
1-ethyl-6-methyl-3-[(Z)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
1-ethyl-6-methyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-1-butyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-1-cyclopentyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-1-[2-(dimethylamino)ethyl]-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-6-methyl-1-(propan-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e,1,2,4]triazine-5,7(1H,6H)dione | - |
Trypanosoma brucei | |
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
3-(5-bromothiophen-2-yl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | - |
Trypanosoma brucei | |
6-bromo-2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide | linear mixed-type inhibition | Trypanosoma brucei | |
6-bromo-2-(5-methylfuran-2-yl)-N-(4-sulfamoylbenzyl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-2-(5-methylfuran-2-yl)-N-(morpholin-4-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide | linear mixed-type inhibition | Trypanosoma brucei | |
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-3-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-2-(5-methylfuran-2-yl)-N-phenethylquinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N,N,N-trimethyl-2-(2-(5-methylfuran-2-yl)quinoline-4-carboxamido)ethanaminium iodide | - |
Trypanosoma brucei | |
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | linear mixed-type inhibition | Trypanosoma brucei | |
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylthiophen-2-yl)-quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N-(2-(dimethylamino)ethyl)-2-(furan-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N-(2-(methylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N-(furan-2-ylmethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N-[2-(dimethylamino)ethyl]-2-(pyridin-4-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N-[2-(dimethylamino)ethyl]-2-phenylquinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-chloro-2-(5-methylfuran-2-yl)-N-[3-(morpholin-4-yl)propyl]quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-chloro-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
6-chloro-N-[2-(dimethylamino)ethyl]-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
7-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
8-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
N-(2-(dimethylamino)ethyl)-6-fluoro-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei | |
N-benzyl-6-bromo-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma brucei | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma brucei |
TryR | - |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma brucei | |
NADPH | - |
Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0011 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-(2-(methylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.0012 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N,N,N-trimethyl-2-(2-(5-methylfuran-2-yl)quinoline-4-carboxamido)ethanaminium iodide | |
0.0017 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.0026 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 1-ethyl-6-methyl-3-[(Z)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0042 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide | |
0.0047 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide | |
0.0051 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 8-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.0051 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.0072 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-3-yl)quinoline-4-carboxamide | |
0.0084 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-2-(5-methylfuran-2-yl)-N-(4-sulfamoylbenzyl)quinoline-4-carboxamide | |
0.0086 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 1,6-dimethyl-3-(4-methylphenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0102 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0113 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0116 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-chloro-2-(5-methylfuran-2-yl)-N-[3-(morpholin-4-yl)propyl]quinoline-4-carboxamide | |
0.0128 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 1-ethyl-6-methyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.013 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromothiophen-2-yl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0144 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.0152 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 1-ethyl-6-methyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0265 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-chloro-N-[2-(dimethylamino)ethyl]-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide | |
0.0324 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-(2-(dimethylamino)ethyl)-2-(furan-2-yl)quinoline-4-carboxamide | |
0.05 | - |
IC50 above 0.05 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-6-methyl-1-(propan-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.092 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.0963 | - |
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-[2-(dimethylamino)ethyl]-2-(pyridin-4-yl)quinoline-4-carboxamide | |
0.1 | - |
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | N-benzyl-6-bromo-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylthiophen-2-yl)-quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-2-(5-methylfuran-2-yl)-N-phenethylquinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | N-(2-(dimethylamino)ethyl)-6-fluoro-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e,1,2,4]triazine-5,7(1H,6H)dione | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-1-[2-(dimethylamino)ethyl]-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-1-butyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.1 | - |
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 3-(5-bromo-2-fluorophenyl)-1-cyclopentyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-[2-(dimethylamino)ethyl]-2-phenylquinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-2-(5-methylfuran-2-yl)-N-(morpholin-4-yl)quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 6-bromo-N-(furan-2-ylmethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C | Trypanosoma brucei | 1-ethyl-6-methyl-3-(pyridin-3-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione |