Literature summary for 1.8.1.12 extracted from

Porcal, W.; Hernandez, P.; Boiani, L.; Boiani, M.; Ferreira, A.; Chidichimo, A.; Cazzulo, J.J.; Olea-Azar, C.; Gonzalez, M.; Cerecetto, H.
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle (2008), Bioorg. Med. Chem., 16, 6995-7004.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(benzofuroxan-5-ylmethyloxy)benzaldehyde amidinohydrazone	50% of inhibition at a inhibitor dose of 0.1 mM, 30% of inhibition at a inhibitor dose of 0.04 mM	Trypanosoma cruzi
benzofuroxan-5-carboxaldehyde thiosemicarbazone	19% of inhibition at a inhibitor dose of 0.1 mM, 9% of inhibition at a inhibitor dose of 0.04 mM	Trypanosoma cruzi
N4-allyl benzofuroxan-5-carboxaldehyde thiosemicarbazone	9% of inhibition at a inhibitor dose of 0.1 mM, 13% of inhibition at a inhibitor dose of 0.04 mM	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADPH + trypanothione disulfide + H+	100 microM NADPH, 105 or 93 microM trypanothione disulfide, pH 7.5, 25°C	Trypanosoma cruzi	trypanothione + NADP+	-	?
NADPH + trypanothione disulfide + H+	100 microM NADPH, 105 or 93 microM trypanothione disulfide, pH 7.5, 25°C	Trypanosoma cruzi Tulahuen 2	trypanothione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
trypanothione reductase	-	Trypanosoma cruzi

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at pH 7.5	Trypanosoma cruzi

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at 25°C	Trypanosoma cruzi

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Release 2023.1 (January 2023)