Application | Comment | Organism |
---|---|---|
medicine | hypnophilin is good candidate for developing new drugs against Chagas disease | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
crude extract of Lentinus strigosus | 100% inhibition of trypanothione reductase | Trypanosoma cruzi | |
dihydrohypnophilin | no inhibitory activity | Trypanosoma cruzi | |
hypnophilin | 100% inhibition of trypanothione reductase, reduces the proliferation of human peripheral blood monocluear cells, not cytotoxic for lymphocytes and monocytes | Trypanosoma cruzi | |
additional information | neopanepoxydol has no inhibitory activity | Trypanosoma cruzi | |
panepoxydone | 95% inhibition of trypanothione reductase | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid) | - |
Trypanosoma cruzi | trypanothione disulfide + thionitrobenzoate | - |
? | |
trypanothione + NADP+ | - |
Trypanosoma cruzi | trypanothione disulfide + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | TR | Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | - |
using recombinant trypanothione reductase from Trypanosoma cruzi | Trypanosoma cruzi | hypnophilin | |
0.0025 | - |
assay with Trypanosoma cruzi amastigotes | Trypanosoma cruzi | hypnophilin | |
0.0389 | - |
- |
Trypanosoma cruzi | panepoxydone |