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Literature summary for 1.8.1.12 extracted from

  • Cota, B.B.; Rosa, L.H.; Fagundes, E.M.; Martins-Filho, O.A.; Correa-Oliveira, R.; Romanha, A.J.; Rosa, C.A.; Zani, C.L.
    A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation (2008), Mem. Inst. Oswaldo Cruz, 103, 263-270.
    View publication on PubMed

Application

Application Comment Organism
medicine hypnophilin is good candidate for developing new drugs against Chagas disease Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
crude extract of Lentinus strigosus 100% inhibition of trypanothione reductase Trypanosoma cruzi
dihydrohypnophilin no inhibitory activity Trypanosoma cruzi
hypnophilin 100% inhibition of trypanothione reductase, reduces the proliferation of human peripheral blood monocluear cells, not cytotoxic for lymphocytes and monocytes Trypanosoma cruzi
additional information neopanepoxydol has no inhibitory activity Trypanosoma cruzi
panepoxydone 95% inhibition of trypanothione reductase Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid)
-
Trypanosoma cruzi trypanothione disulfide + thionitrobenzoate
-
?
trypanothione + NADP+
-
Trypanosoma cruzi trypanothione disulfide + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
trypanothione reductase TR Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
using recombinant trypanothione reductase from Trypanosoma cruzi Trypanosoma cruzi hypnophilin
0.0025
-
assay with Trypanosoma cruzi amastigotes Trypanosoma cruzi hypnophilin
0.0389
-
-
Trypanosoma cruzi panepoxydone