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Literature summary for 1.8.1.12 extracted from

  • Meiering, S.; Inhoff, O.; Mies, J.; Vincek, A.; Garcia, G.; Kramer, B.; Dormeyer, M.; Krauth-Siegel, R.L.
    Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis (2005), J. Med. Chem., 48, 4793-4802.
    View publication on PubMed
Search for more literature for 1.8.1.12

Inhibitors

Inhibitors Comment Organism Structure
1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] more than 90% inhibition at 0.1 mM Trypanosoma cruzi
1-(1H-indol-5-yl)-N-[(4-methylpiperazin-1-yl)methyl]methanediamine 0.1 mM, 31% or 39% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide, respectively Trypanosoma cruzi
1-(3-bromothiophen-2-yl)-N-(pyridin-3-ylmethyl)methanediamine 0.1 mM, 15% or 14% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide, respectively Trypanosoma cruzi
N-(pyridin-3-ylmethyl)-1-thiophen-2-ylmethanediamine 0.1 mM, 10% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide Trypanosoma cruzi
N-[(4-methylpiperazin-1-yl)methyl]-1-thiophen-2-ylmethanediamine 0.1 mM, 10% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide Trypanosoma cruzi
N-[2-[(naphthalen-1-ylacetyl)amino]ethyl]-4-[[(3-nitrophenyl)(oxo)acetyl]amino]piperidine-4-carboxamide 0.1 mM Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
TR
-
 Trypanosoma cruzi
trypanothione reductase
-
 Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide]
-
 Trypanosoma cruzi
0.009
-
 N-[2-[(naphthalen-1-ylacetyl)amino]ethyl]-4-[[(3-nitrophenyl)(oxo)acetyl]amino]piperidine-4-carboxamide mixed type inhibitor, 0.1 mM Trypanosoma cruzi