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Literature summary for 1.8.1.12 extracted from

  • Inhoff, O.; Richards, J.M.; Briet, J.W.; Lowe, G.; Krauth-Siegel, R.L.
    Coupling of a competitive and an irreversible ligand generates mixed type inhibitors of Trypanosoma cruzi trypanothione reductase (2002), J. Med. Chem., 45, 4524-4530.
    View publication on PubMed
Search for more literature for 1.8.1.12

Inhibitors

Inhibitors Comment Organism Structure
2-methoxy-6-chloro-9-aminoacridine/2-hydroxyethanethiolate (2,2':6',2''-terpyridine)platinum(II) complex 4 chimeric compound variants, competitive and irreversible inhibition, probably Cys52 of the enzyme is specifically modified, 4'-substituted (terpyridine)platinum(II) containing complexes do not inhibit irreversibly Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma cruzi enzyme is required for maintaining the reducing intracellular redox equilibrium, trypanosomes lacking the enzyme are avirulent and show increased sensitivity to oxidative stress ?
-
 ?
trypanothione disulfide + NADPH Trypanosoma cruzi highly specific for trypanothione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is required for maintaining the reducing intracellular redox equilibrium, trypanosomes lacking the enzyme are avirulent and show increased sensitivity to oxidative stress Trypanosoma cruzi ?
-
 ?
trypanothione disulfide + NADPH highly specific for Trypanosoma cruzi trypanothione + NADP+
-
 ?
trypanothione disulfide + NADPH i.e. bisglutathionylspermidine Trypanosoma cruzi trypanothione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
TR
-
 Trypanosoma cruzi
trypanothione reductase
-
 Trypanosoma cruzi

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
additional information enzyme is a flavoprotein Trypanosoma cruzi
NADPH
-
 Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Trypanosoma cruzi