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Literature summary for 1.8.1.12 extracted from

  • Tamayo, E.M.; Iturbe, A.; Hernandez, E.; Hurtado, G.; de Lourdes Gutierrez, X.M.; Rosales, J.L.; Woolery, M.; Ondarza, R.N.
    Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug target (2005), Biotechnol. Appl. Biochem., 41, 105-115.
    View publication on PubMed
Search for more literature for 1.8.1.12

Application

Application Comment Organism
pharmacology enzyme is a drug target Entamoeba histolytica

Cloned(Commentary)

Cloned (Comment) Organism
gene EHTR, DNA and amino acid sequence determination and analysis, phylogenetic analysis Entamoeba histolytica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trypanothione disulfide + NADPH Entamoeba histolytica
-
 trypanothione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica Q8MZR8 putative, fragment; human parasite, strain HK9
-

Reaction

Reaction Comment Organism Reaction ID
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ reducing catalytic site CVNVGC Entamoeba histolytica
a

Source Tissue

Source Tissue Comment Organism Textmining
trophozoite
-
 Entamoeba histolytica
-
trypanosomoid form
-
 Entamoeba histolytica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
 Entamoeba histolytica trypanothione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
TR
-
 Entamoeba histolytica
trypanothione reductase
-
 Entamoeba histolytica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Entamoeba histolytica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Entamoeba histolytica

Cofactor

Cofactor Comment Organism Structure
FAD 2 molecules per enzyme dimer Entamoeba histolytica
NADPH dependent on Entamoeba histolytica