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Literature summary for 1.8.1.12 extracted from
- New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase (1997), Bioorg. Med. Chem., 5, 1249-1256.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| clomipramine | - |
Trypanosoma cruzi |  |
| phenothiazines | - |
Trypanosoma cruzi | |
| spermidine derivatives | derivatives of 2-amino-diphenylsulfide + phenothiazine | Trypanosoma cruzi | |
| spermine derivatives | derivatives of 2-amino-diphenylsulfide + phenothiazine | Trypanosoma cruzi |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
- |
- |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 21 | - |
assay at | Trypanosoma cruzi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.25 | - |
assay at | Trypanosoma cruzi |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Trypanosoma cruzi | |
| NADPH | - |
Trypanosoma cruzi | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | derivatives of 2-amino-diphenylsulfide + phenothiazine | Trypanosoma cruzi | |
| 0.01 | - |
phenothiazines | - |
Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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