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Literature summary for 1.8.1.12 extracted from
- Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase (1999), Biochem. Pharmacol., 58, 1791-1799.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi | |
| additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma congolense |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | - |
Trypanosoma congolense |
| medicine | nitrofuran derivatives show antiparasitic effect on the trypanocidal drug design target trypanothione reductase | Trypanosoma cruzi |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chinifur | - |
Trypanosoma congolense |  |
| chinifur | increases oxidation of the enzyme | Trypanosoma cruzi | |
| menadione | - |
Trypanosoma cruzi | |
| nifuraxide | increases oxidation of the enzyme | Trypanosoma cruzi | |
| nifuroxime | increases oxidation of the enzyme | Trypanosoma cruzi | |
| nifurprazine | increases oxidation of the enzyme | Trypanosoma cruzi | |
| nifurtimox | - |
Trypanosoma cruzi | |
| Plumbagin | - |
Trypanosoma cruzi | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
trypanothione disulfide | - |
Trypanosoma cruzi | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trypanothione disulfide + NADPH | Trypanosoma cruzi | - |
trypanothione + NADP+ | - |
? | |
| trypanothione disulfide + NADPH | Trypanosoma congolense | - |
trypanothione + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma congolense | - |
- |
- |
| Trypanosoma cruzi | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | chinifur increases the oxidation of the enzyme 40fold | Trypanosoma cruzi | ? | - |
? | |
| additional information | reduces inhibitory nitrofurans, e.g. chinifur, nifuroxamide, nifuroxime and nifurprazine, and naphthoqinone derivatives | Trypanosoma cruzi | ? | - |
? | |
| trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? | |
| trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
r | |
| trypanothione disulfide + NADPH | - |
Trypanosoma congolense | trypanothione + NADP+ | - |
? | |
| trypanothione disulfide + NADPH | - |
Trypanosoma congolense | trypanothione + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TR | - |
Trypanosoma cruzi |
| TR | - |
Trypanosoma congolense |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Trypanosoma cruzi |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Trypanosoma cruzi | |
| FAD | - |
Trypanosoma congolense | |
| NADPH | - |
Trypanosoma cruzi | |
| NADPH | - |
Trypanosoma congolense | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0045 | - |
chinifur | - |
Trypanosoma congolense | |
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