Literature summary for 1.8.1.12 extracted from

Krauth-Siegel, R.L.; Jockers-Scheruebl, M.C.; Becker, K.; Schirmer, R.H.
NADPH-dependent disulphide reductases (1989), Biochem. Soc. Trans., 17, 315-317.

Search for more literature for 1.8.1.12

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activity is dependent on a redox-active cysteine at the active centre	Crithidia fasciculata
additional information	activity is dependent on a redox-active cysteine at the active centre	Trypanosoma cruzi
additional information	activity is dependent on a redox-active cysteine at the active centre	Trypanosoma congolense

Application

Application	Comment	Organism
medicine	potential target for drug design against trypanosomiasis	Crithidia fasciculata
medicine	potential target for drug design against trypanosomiasis	Trypanosoma cruzi
medicine	potential target for drug design against trypanosomiasis	Trypanosoma congolense

Inhibitors

Inhibitors	Comment	Organism	Structure
nifurtimox	weak inhibitor	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Crithidia fasciculata	-	insect-parasitic trypanosomatid	-
Trypanosoma congolense	-	-	-
Trypanosoma cruzi	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+	mechanistic scheme for NAD(P)H:disulfide oxidoreductases	Crithidia fasciculata	a
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+	mechanistic scheme for NAD(P)H:disulfide oxidoreductases	Trypanosoma cruzi	a
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+	mechanistic scheme for NAD(P)H:disulfide oxidoreductases	Trypanosoma congolense	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trypanothione disulfide + NADPH	-	Crithidia fasciculata	trypanothione + NADP+	-	r
trypanothione disulfide + NADPH	-	Trypanosoma cruzi	trypanothione + NADP+	-	r
trypanothione disulfide + NADPH	-	Trypanosoma congolense	trypanothione + NADP+	-	r

Subunits

Subunits	Comment	Organism
dimer	-	Crithidia fasciculata
dimer	-	Trypanosoma cruzi
dimer	-	Trypanosoma congolense

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Crithidia fasciculata
FAD	-	Trypanosoma cruzi
FAD	-	Trypanosoma congolense
NADPH	-	Crithidia fasciculata
NADPH	-	Trypanosoma cruzi
NADPH	-	Trypanosoma congolense

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.15	-	nifurtimox	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)