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Literature summary for 1.7.2.3 extracted from
- Genetic analysis of trimethylamine N-oxide reductases in the light organ symbiont Vibrio fischeri ES114 (2008), J. Bacteriol., 190, 5814-5823.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| GFP-tagged enzyme expression, the genome sequence of Vibrio fischeri reveals three putative TMAO reductase operons, transcriptional regulation, overview | Aliivibrio fischeri |
| the torECA promoter, and to a lesser extent the torYZ and dmsABC promoters, are active during symbiotic colonization of juvenile Euprymna scolopes, transcriptional regulation, overview | Euprymna scolopes |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of different mutant strains lacking torECA, torYZ, or dmsABC gene activity, the strain lacking all three enzymes is designated as AKD806, strain AKD806 has no symbiotic defect but under laboratory conditions shows reduced growth in the presence of trimethylamine-N-oxide with maximum cell densities similar to the wild type grown in the absence of trimethylamine-N-oxide | Aliivibrio fischeri ES114 |
| additional information | a Vibrio fischeri strain lacking TMAO reductase activity displays no discernible colonization defect over the first 48 h | Aliivibrio fischeri |
| additional information | a Vibrio fischeri strain lacking TMAO reductase activity displays no discernible colonization defect over the first 48 h | Euprymna scolopes |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trimethylamine-N-oxide + electron donor | Aliivibrio fischeri ES114 | anaerobic respiration | trimethylamine + oxidized electron donor + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aliivibrio fischeri | - |
wild-type strain ES114, and mutant strains strains JB1, AMJ2, and KV1585 | - |
| Aliivibrio fischeri ES114 | - |
symbiotic bacterium associated with the light organ of the adult Hawaiian bobtail squid Euprymna scolopes, construction of different mutant strains lacking torECA, torYZ, or dmsABC gene activity, the strain lacking all three enzymes is designated as AKD806 | - |
| Euprymna scolopes | - |
Hawaiian bobtail squid | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| light organ | - |
Euprymna scolopes | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trimethylamine-N-oxide + electron donor | anaerobic respiration | Aliivibrio fischeri ES114 | trimethylamine + oxidized electron donor + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | two other genes (torYZ and dmsABC) coding for enzymes with trimethylamine-N-oxide reductase function identified, but they are much less active than the torECA gene, experimental data suggest that torECA encodes the major TMAO reductase under laboratory culture conditions and that TorYZ and DmsABC do not significantly contribute to trimethylamine-N-oxide reduction | Aliivibrio fischeri ES114 |
| TMAO reductase | - |
Aliivibrio fischeri |
| TMAO reductase | - |
Aliivibrio fischeri ES114 |
| TMAO reductase | - |
Euprymna scolopes |
| torECA gene product | - |
Aliivibrio fischeri ES114 |
| trimethylamine N-oxide reductase | - |
Aliivibrio fischeri |
| trimethylamine N-oxide reductase | - |
Euprymna scolopes |
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