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Literature summary for 1.7.1.7 extracted from
- Structural and dynamical impact of water molecules at substrate- or product-binding sites in human GMPR enzyme A study by molecular dynamics simulations (2021), J. Phys. Chem. B, 125, 1351-1362 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Disulfiram | - |
Homo sapiens |  |
| mizoribine | - |
Homo sapiens | |
| ribavirin | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GMP + NADPH + H+ | Homo sapiens | - |
IMP + NH3 + NADP+ | - |
r | |
| IMP + NH3 + NADP+ | Homo sapiens | - |
GMP + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P36959 | - |
- |
| Homo sapiens | Q9P2T1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GMP + NADPH + H+ | - |
Homo sapiens | IMP + NH3 + NADP+ | - |
r | |
| IMP + NH3 + NADP+ | - |
Homo sapiens | GMP + NADPH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GMPR-I | - |
Homo sapiens |
| GMPR-II | - |
Homo sapiens |
| guanosine monophosphate reductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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