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Literature summary for 1.7.1.6 extracted from

  • Huang, M.T.; Miwa, G.T.; Cronheim, N.; Lu, A.Y.H.
    Rat liver cytosolic azoreductase. Electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme (1979), J. Biol. Chem., 254, 11223-11227.
    View publication on PubMed
Search for more literature for 1.7.1.6

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol 0.0001 mM, 50% inhibition of methyl red reduction, 0.0004 mM, 90% inhibition, competitive vs. NADPH noncompetitve vs. methyl red Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
dicoumarol
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
57
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricyanide + NADPH
-
 Rattus norvegicus 2 ferrocyanide + NADP+ + H+
-
 ?
4-(dimethylamino)azobenzene + 2 NADPH electron transport protein Rattus norvegicus N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ + 2 H+
-
 ?
NADPH + 9,10-phenanthrenequinone
-
 Rattus norvegicus NADP+ + 9,10-phenanthrenequinol
-
 ?
NADPH + H+ + 1,4-benzoquinone
-
 Rattus norvegicus NADP+ + 1,4-benzoquinol
-
 ?
NADPH + H+ + 1,4-naphthoquinone
-
 Rattus norvegicus NADP+ + 1,4-naphthoquinol
-
 ?
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Rattus norvegicus NADP+ + reduced 2,6-dichlorophenolindophenol
-
 ?
NADPH + oxidized cytochrome c in the presence of menadione as electron carrier Rattus norvegicus NADP+ + reduced cytochrome c
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00003
-
 dicoumarol vs. NADPH Rattus norvegicus
0.00011
-
 dicoumarol vs. methyl red Rattus norvegicus