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Literature summary for 1.6.5.9 extracted from

  • Verner, Z.; Skodova, I.; Polakova, S.; Durisova-Benkovicova, V.; Horvath, A.; Lukes, J.
    Alternative NADH dehydrogenase (NDH2): intermembrane-space-facing counterpart of mitochondrial complex I in the procyclic Trypanosoma brucei (2013), Parasitology, 140, 328-337.
    View publication on PubMed
Search for more literature for 1.6.5.9

Protein Variants

Protein Variants Comment Organism
additional information NDH2 gene silencing using tetracycline-inducible RNAi Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + H+ + ubiquinone Trypanosoma brucei
-
 NAD+ + ubiquinol
-
 ?
NADH + H+ + ubiquinone Trypanosoma brucei 29-13
-
 NAD+ + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-
Trypanosoma brucei 29-13
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + ubiquinone
-
 Trypanosoma brucei NAD+ + ubiquinol
-
 ?
NADH + H+ + ubiquinone
-
 Trypanosoma brucei 29-13 NAD+ + ubiquinol
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Trypanosoma brucei

Synonyms

Synonyms Comment Organism
alternative NADH dehydrogenase
-
 Trypanosoma brucei
alternative rotenone-insensitive NADH:Q oxidoreductase
-
 Trypanosoma brucei
NADH: ubiquinone-2 oxidoreductase
-
 Trypanosoma brucei
NADHQ2
-
 Trypanosoma brucei
NDH2
-
 Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction the induced RNAi cell line exhibits slower growth, decreased mitochondrial membrane potential and lower sensitivity of respiration to inhibitors. Mitochondrial membrane potential is altered in NDH2 knockdown. Growth phenotype of procyclic Trypanosoma brucei interfered against NDH2, overview Trypanosoma brucei
physiological function NDH2 is a part of the respiratory chain that does not pump protons across the inner membrane. NDH2 is the major NADH: ubiquinone oxidoreductase responsible for cytosolic and not for mitochondrial NAD+ regeneration in the mitochondrion of procyclic Trypanosoma brucei. thatNDH2is facing intermembrane space, rendering complex I responsible only for the regeneration of matrix NAD+. Ability of NDH2 to fully compensate for the loss of complex I. NDH2 is essential for the maintenance of mitochondrial membrane potential in procyclic Trypanosoma brucei Trypanosoma brucei