Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.5.5 extracted from

  • Duhaiman, A.S.
    Kinetic properties of camel lens zeta-crystallin (1996), Int. J. Biochem. Cell Biol., 28, 1163-1168.
    View publication on PubMed
Search for more literature for 1.6.5.5

Inhibitors

Inhibitors Comment Organism Structure
2,3-Dimercaptopropanol
-
 Camelus dromedarius
5,5'-dithiobis(2-nitrobenzoate)
-
 Camelus dromedarius
ADP 10% inhibition at 0.2 mM Camelus dromedarius
Cu2+ 25% inhibition at 1 mM Camelus dromedarius
dicoumarol
-
 Camelus dromedarius
dithiothreitol strong competitive inhibition with respect to 9,10-phenanthrenequinone Camelus dromedarius
FAD 60% inhibition at 0.2 mM Camelus dromedarius
FMN 40% inhibition at 0.2 mM Camelus dromedarius
NAD+ 5% inhibition at 0.2 mM Camelus dromedarius
NADP+ mixed-type inhibition with respect to NADPH, competitive with respect to 9,10-phenanthrenequinone Camelus dromedarius
NEM
-
 Camelus dromedarius
warfarin
-
 Camelus dromedarius
Zn2+ 25% inhibition at 1 mM Camelus dromedarius

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0024
-
 1,2-naphthoquinone
-
 Camelus dromedarius
0.0069
-
 NADPH
-
 Camelus dromedarius
0.013
-
 oxidized 2,6-dichlorophenolindophenol
-
 Camelus dromedarius
0.017
-
 9,10-phenanthrenequinone
-
 Camelus dromedarius
0.065
-
 1,4-benzoquinone
-
 Camelus dromedarius
0.26
-
 1,4-Naphthoquinone
-
 Camelus dromedarius

Organism

Organism UniProt Comment Textmining
Camelus dromedarius
-
 camel
-

Reaction

Reaction Comment Organism Reaction ID
NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone reaction with 9,10-phenanthrenequinone and NADPH proceeds through a ping-pong mechanism Camelus dromedarius
a

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Camelus dromedarius
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-naphthoquinone + NADPH
-
 Camelus dromedarius 1,2-naphthoquinol + NADP+
-
 ?
1,4-benzoquinone + NADPH
-
 Camelus dromedarius 1,4-benzosemiquinone + NADP+
-
 ?
1,4-naphthoquinone + NADPH + H+
-
 Camelus dromedarius 1,4-naphthosemiquinone + NADP+
-
 ?
9,10-phenanthrenequinone + NADPH best substrate Camelus dromedarius 9,10-phenanthrenesemiquinone + NADP+
-
 ?
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Camelus dromedarius NADP+ + reduced 2,6-dichlorophenolindophenol
-
 ?