Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[3,5-dinitro-2-(1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-1-oxohydrazinium | - |
Homo sapiens | |
10-nitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | |
10-nitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline-8-carboxamide 12-oxide | - |
Homo sapiens | |
10-nitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline-9-carboxamide 12-oxide | - |
Homo sapiens | |
2,10-dinitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | |
2,4-dinitro-5-(1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | |
2,4-dinitro-5-(5-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | |
2,4-dinitro-5-(7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | |
2-(2,4,6-trinitrophenyl)-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
2-(2,4-dinitrophenyl)-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
2-(2,4-dinitrophenyl)-5-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
2-(2,4-dinitrophenyl)-7-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-5-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-7-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | |
3,5-dinitro-2-(1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | |
3,5-dinitro-2-(1,2,3,4-tetrahydronaphthalen-2-yl)benzoic acid | - |
Homo sapiens | |
3,5-dinitro-2-(5-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzoic acid | - |
Homo sapiens | |
3,5-dinitro-2-(7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzoic acid | - |
Homo sapiens | |
4,10-dinitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | |
4,10-dinitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline-9-carboxamide 12-oxide | - |
Homo sapiens | |
4,10-dinitro-8-(trifluoromethyl)-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | |
additional information | synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1, NQO1, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.001 | - |
below, recombinant enzyme NQO1, substrate 10a, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 10f, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 10g, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 10h, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 10o, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 11d, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 11e, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 11h, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 11i, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 11k, pH not specified in the publication, 37°C | Homo sapiens |
0.001 | - |
below, recombinant enzyme NQO1, substrate 11l, pH not specified in the publication, 37°C | Homo sapiens |
0.0014 | - |
recombinant enzyme NQO1, substrate 10k, pH not specified in the publication, 37°C | Homo sapiens |
0.0062 | - |
recombinant enzyme NQO1, substrate 5-(aziridin-1-yl)-2,4-dinitrobenzamide, i.e. CB-1954, pH not specified in the publication, 37°C | Homo sapiens |
0.011 | - |
recombinant enzyme NQO1, substrate 10c, pH not specified in the publication, 37°C | Homo sapiens |
0.013 | - |
recombinant enzyme NQO1, substrate 2-(3,5-dinitropyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline, pH not specified in the publication, 37°C | Homo sapiens |
0.016 | - |
recombinant enzyme NQO1, substrate 11a, pH not specified in the publication, 37°C | Homo sapiens |
0.02 | - |
recombinant enzyme NQO1, substrate 10n, pH not specified in the publication, 37°C | Homo sapiens |
0.038 | - |
recombinant enzyme NQO1, substrate 10j, pH not specified in the publication, 37°C | Homo sapiens |
0.042 | - |
recombinant enzyme NQO1, substrate 10e, pH not specified in the publication, 37°C | Homo sapiens |
0.053 | - |
recombinant enzyme NQO1, substrate 10d, pH not specified in the publication, 37°C | Homo sapiens |
0.076 | - |
recombinant enzyme NQO1, substrate 10m, pH not specified in the publication, 37°C | Homo sapiens |
0.11 | - |
recombinant enzyme NQO1, substrate 10b, pH not specified in the publication, 37°C | Homo sapiens |
0.17 | - |
recombinant enzyme NQO1, substrate 5,6-dihydro-10-nitropyrido[3'',2'':4',5']imidazo[2',1'-a]isoquinoline 12-oxide, pH not specified in the publication, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with 2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-5-nitro-1,2,3,4-tetrahydronaphthalene and 2-(2,4-dinitrophenyl)-7-nitro-1,2,3,4-tetrahydronaphthalene | Homo sapiens | ? | - |
? | |
NADH + H+ + 1-[3,5-dinitro-2-(1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-1-oxohydrazinium | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 10-nitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 10-nitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline-8-carboxamide 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 10-nitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline-9-carboxamide 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2,10-dinitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2,4-dinitro-5-(1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2,4-dinitro-5-(5-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2,4-dinitro-5-(7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-(2,4,6-trinitrophenyl)-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-(2,4-dinitrophenyl)-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-(2,4-dinitrophenyl)-5-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-(3,5-dinitropyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-5-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 2-[2,4-dinitro-6-(trifluoromethyl)phenyl]-7-nitro-1,2,3,4-tetrahydronaphthalene | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 3,5-dinitro-2-(1,2,3,4-tetrahydronaphthalen-2-yl)benzamide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 3,5-dinitro-2-(1,2,3,4-tetrahydronaphthalen-2-yl)benzoic acid | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 3,5-dinitro-2-(7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)benzoic acid | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 4,10-dinitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 4,10-dinitro-5,6-dihydrobenzimidazo[2,1-a]isoquinoline-9-carboxamide 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 4,10-dinitro-8-(trifluoromethyl)-5,6-dihydrobenzimidazo[2,1-a]isoquinoline 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 5,6-dihydro-10-nitropyrido[3'',2'':4',5']imidazo[2',1'-a]isoquinoline 12-oxide | - |
Homo sapiens | ? | - |
? | |
NADH + H+ + 5-(aziridin-1-yl)-2,4-dinitrobenzamide | i.e. CB-1954 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H: quinone oxidoreductase 1 | - |
Homo sapiens |
NQO1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |