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Literature summary for 1.6.5.2 extracted from

  • Mendoza, M.F.; Hollabaugh, N.M.; Hettiarachchi, S.U.; McCarley, R.L.
    Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups (2012), Biochemistry, 51, 8014-8026.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.5.2

Application

Application Comment Organism
drug development the enzyme is a valuable target for activating stimuli-responsive drug delivery systems based on quinone derivatives, such as prodrugs and liposomes Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics and first-order rate constants with NADH and quinone substrates, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol mainly Homo sapiens 5829
-
endoplasmic reticulum
-
 Homo sapiens 5783
-
extracellular
-
 Homo sapiens
-
-
membrane
-
 Homo sapiens 16020
-
mitochondrion
-
 Homo sapiens 5739
-
additional information NQO1 is located mainly in the cytosol of cells, but can be found also in the nucleus, endoplasmic reticulum, cellular membrane, and mitochondria, as well as extracellularly Homo sapiens
-
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell overexpression Homo sapiens
-
commercial preparation recombinant human NQO1 Homo sapiens
-
non-small cell lung cancer cell overexpression Homo sapiens
-
pancreatic cancer cell overexpression Homo sapiens
-

Subunits

Subunits Comment Organism
homodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
DT-diaphorase
-
 Homo sapiens
NAD(P)H:quinone oxidoreductase-1
-
 Homo sapiens
NQO1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22 26 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADH
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
additional information the homodimeric flavoprotein is unique among reductases, as it catalyzes the direct two-electron reduction of a wide variety quinones using NADH or NADPH as cofactor. Substrate docking studies, overview Homo sapiens