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Literature summary for 1.6.5.2 extracted from

  • Adler, J.; Reuven, N.; Kahana, C.; Shaul, Y.
    c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics (2010), Mol. Cell. Biol., 30, 3767-3778.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.5.2

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
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 Homo sapiens
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HEK-293 cell
-
 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
NAD(P)H:quinone oxidoreductase 1
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 Homo sapiens
NQO1
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 Homo sapiens

General Information

General Information Comment Organism
physiological function NQO1, a 20S proteasome gatekeeper, binds and induces robust c-Fos accumulation by blocking the ubiquitin-independent degradation pathway. NQO1 protects monomeric c-Fos from proteasomal ubiquitin-independent degradation. NQO1 is important to ensure immediate c-Fos accumulation in response to serum Homo sapiens