Application | Comment | Organism |
---|---|---|
medicine | neuroprotective role of DT-diaphorase against aminochrome neurotoxicity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | lack of effect of inhibition of DT-diaphorase by dicoumarol, when the cells are incubated with dopamine and reserpine. Significant cell death only when RCSN-3 cells are incubated with reserpine and dopamine together with the DT-diaphorase inhibitor dicoumarol | Rattus norvegicus | |
reserpine | competitive inhibitor of DT-diaphorase | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by affinity chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RCSN-3 cell | - |
Rattus norvegicus | - |
substantia nigra | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
menadione + NADH | - |
Rattus norvegicus | reduced menadione + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DT-diaphorase | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.024 | - |
reserpine | - |
Rattus norvegicus |