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Literature summary for 1.6.5.2 extracted from

  • Guo, W.; Reigan, P.; Siegel, D.; Zirrolli, J.; Gustafson, D.; Ross, D.
    The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins (2006), Mol. Pharmacol., 70, 1194-1203.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ES 936
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme, stably transfected to breast cancer cell line MDA468
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17-(2-dimethylylamino)ethylamino-17-demethoxygeldanamycin + NAD(P)H + H+
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Homo sapiens reduced 17-(2-dimethylylamino)ethylamino-17-demethoxygeldanamycin + NADP+ reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin ?
17-(2-pyrrolidin-1-yl)ethylamino-17-demethoxygeldanamycin + NAD(P)H + H+
-
Homo sapiens reduced 17-(2-pyrrolidin-1-yl)ethylamino-17-demethoxygeldanamycin + NADP+ reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin ?
17-allylamino-17-demethoxygeldanamycin + NAD(P)H + H+
-
Homo sapiens reduced 17-allylamino-17-demethoxygeldanamycin + NADP+ reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin ?
17-amino-17-demethoxygeldanamycin + NAD(P)H + H+
-
Homo sapiens reduced 17-amino-17-demethoxygeldanamycin + NADP+ reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin ?
geldanamycin + NAD(P)H + H+
-
Homo sapiens reduced geldanamycin + NADP+ reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin ?